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"Adult stem cells - because they can be harvested so easily and abundantly from the skin - open up the fascinating frontiers of regenerative medicine and will undoubtedly lead to more effective therapeutic applications in the future."
		Dr. Markus Frank M.D., Assistant Professor Harvard Medical School, is TICEBA's scientific advisor. He is currently engaged in a number of basic research investigations and is a member of the medical faculty at Harvard University in Cambridge, Massachusetts, USA. Dr. Frank brings considerable knowledge and expertise in the field of stem cell research to our venture.

Academic Appointments • Instructor in Medicine, Harvard Medical School, Boston, MA • Principal Investigator Appointments and Responsibilities Hospital or Affiliated Institution Appointments: • Staff Physician, Department of Medicine, V.A. Medical Center, West Roxbury, • Boston, MA • Associate Physician, Renal Division, Brigham and Women's Hospital, • Boston, MA • Research Associate, Division of Nephrology, Children's Hospital, Boston, MA • Staff Physician, Department of Medicine, Faulkner Hospital, Boston, MA • Consulting Staff, Department of Medical Oncology, Dana Farber Cancer • Institute, Boston, MA • Member, Cutaneous Oncology and Melanoma Program, Dana-Farber/Harvard • Cancer Center, Boston, MA Hospital & Health Care Organization Clinical Service Responsibilities: • Attending Physician in Medicine/Emergency Medicine, V.A. Medical Center, • West Roxbury • Attending Physician in Nephrology, Brigham and Women's Hospital • Attending Physician in Nephrology, Faulkner Hospital Major Committee Assignments • Abstract Review Committee, Member, American Society of Transplantation • Abstract Review Committee, Member, American Society of Nephrology • Scientific Review Committee, Member, Israel Science Foundation • The Stem Cell Program, Member, Children's Hospital • Harvard Stem Cell Institute, Member, Harvard University • AST Cellular Transplantation Committee, Member, American Society of • Transplantation Professional Societies • American College of Physicians, Member • American Medical Association, Member • American Society of Transplantation, Member; Member Abstract Review • Committee 2002-2006, Scientific Session Co-Chair 2002-2006 • National Kidney Foundation, Member • The Transplantation Society, Member • International Society of Comparative Oncology, Member • American Society of Biochemistry and Molecular Biology, Member • American Society of Human Genetics, Member • American Society for Cell Biology, Member Editorial Boards • Ad-Hoc Reviewer, Journal of the American Society of Nephrology • Ad-Hoc Reviewer, Blood • Ad-Hoc Reviewer, Kidney International • Ad-Hoc Reviewer, Journal of Immunology • Ad-Hoc Reviewer, Molecular BioSystems (Royal Society of Chemistry, • Cambridge, UK) • Ad-Hoc Reviewer, American Journal of Physiology - Cell Physiology • Ad-Hoc Reviewer, Journal of Leukocyte Biology Bibliography Original Articles: • Frank MH, Pomer S. Interferon alpha2b differentially affects proliferation of • two human renal cell carcinoma cell lines differing in the P-glycoprotein- • associated multidrug-resistant phenotype. J Cancer Res Clin Oncol. 1999; • 125(2):117-20. • Frank MH, Denton MD, Alexander SI, Khoury SJ, Sayegh MH, Briscoe DM. • Specific MDR1 Pglycoprotein blockade inhibits human alloimmune T cell • activation in vitro. J Immunol. 2001;166 (4):2451-9. • Frank NY, Pendse SS, Lapchak PH, Margaryan A, Shlain D, Doeing C, Sayegh • MH, Frank MH. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, • a novel human ATP-binding cassette transporter. J Biol Chem. 2003; • 278(47):47156-65. • Lapchak PH, Melter M, Pal S, Flaxenburg JA, Geehan C, Frank MH, • Mukhopadhyay D, Briscoe DM. CD40-induced transcriptional activation • of vascular endothelial growth factor involves a 68- bp region of the • promoter containing a CpG island. Am J Physiol Renal Physiol. 2004; • 287(3):F512-20. • Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, • Sayegh MH, Sadee W, Frank MH. ABCB5-mediated doxorubicin transport and • chemoresistance in human malignant melanoma. Cancer Res. 2005; • 65(10):4320-33. • Lutz NW, Franks SE, Frank MH, Pomer S, Hull WE. Investigation of multidrug • resistance in cultured human renal cell carcinoma cells by 31P-NMR • spectroscopy and treatment survival assays. MAGMA. 2005;18(3):144-61. • Frank NY, Kho AT, Schatton T, Murphy GF, Molloy MJ, Zhan Q, Ramoni MF, • Frank MH, Kohane IS, Gussoni E. Regulation of myogenic progenitor • proliferation in human fetal skeletal muscle by BMP4 and its • antagonist Gremlin. J Cell Biol. 2006 Oct 9; 175(1):99-110. • Pendse SS, Behjati S, Schatton T, Izawa A, Sayegh MH, Frank MH. • P-Glycoprotein Functions as a Differentiation Switch in Antigen Presenting • Cell Maturation. Am J Transplant. 2006 Nov 3. Reviews/Chapters/Editorials: • Pendse S, Briscoe DM, Frank MH. P-glycoprotein and alloimmune T cell • activation. Clinical and Applied Immunology Reviews. 2003;4(1):3-14. • Pendse S, Sayegh MH, Frank MH. P-glycoprotein - a novel therapeutic target • for immunomodulation in clinical transplantation and autoimmunity? Curr Drug • Targets. 2003;4(6):469-76. • Frank MH, Sayegh MH. Immunomodulatory functions of mesenchymal stem • cells. Lancet. 2004;363(9419):1411-2. Books, Monographs, and Textbooks: • Frank MH, Sayegh MH. Transplantation Tolerance. In: Transplantation 1999: • Progress on the Cusp of the Millennium. New York (NY): Lippincott Williams & • Wilkins Healthcare;1999. • Frank MH, Sayegh MH. Immunology and Tolerance. In: Transplantation 2000: • Transplantation at the Millennium. New York (NY): Lippincott Williams & Wilkins • Healthcare;2000. • Frank MH, Sayegh MH. Tolerance: is it time to move to the clinic? In: Current • and Future Immunosuppressive Therapies Following Transplantation. • Dordrecht, The Netherlands: Kluwer Academic Publishers;2001. p. 293-313. • (Mohamed Sayegh and Giuseppe Remuzzi, editors.) • Frank MH, Sayegh MH. Immunology and Tolerance. In: Transplantation 2001. • New York (NY): Lippincott Williams & Wilkins Healthcare;2001. • Frank MH. Briscoe DM. Monoclonal Antibody Targeting of Adhesion Molecules. • In: Current and Future Immunosuppressive Therapies Following • Transplantation. Dordrecht, The Netherlands: Kluwer Academic Publishers; • 2001. p. 249-263. (Mohamed Sayegh and Giuseppe Remuzzi, editors.) Abstracts: • Frank MH, Shedd SF, Lutz NW, Pomer S, Hull WE. 31P Nuclear Magnetic • Resonance Spectroscopy Study of Multidrug Resistance in Human Renal Cell • Carcinoma. Society of Magnetic Resonance in Medicine 12th Annual • Conference New York, NY. 1993:1015. • Shedd SF, Lutz NW, Frank MH, Hull WE. Choline- and Ethanolamine- • Dependent Regulation of Phosphomonoester and Uridine diphospho-hexose • Metabolism in a Human Colon Cancer Cell Line. Society of Magnetic • Resonance in Medicine 12th Annual Conference New York, NY. 1993:262. • Lu R, Frank M, Schuster VL. Genomic Cloning of the Human Prostaglandin • (PG) Transporter "PGT" Gene. Journal of the American Society of Nephrology. • 1996;7:A1997. • Frank MH, Pomer S. IFN-alpha differentially affects proliferation of two renal • cell carcinoma cell lines differing in the P-glycoprotein-associated multidrug • resistance phenotype. UICC 17th International Cancer Congress August 23-28 • 1998, Rio de Janeiro - Brazil. 1998:A1143. • Frank MH, Denton MD, Alexander SI, Khoury SJ, Sayegh MH, Briscoe DM. • P-glycoprotein is functional in antigen- and alloantigen-dependent T cell • activation. Journal of the American Society of Nephrology. 1999;10:A3551. • Denton MD, Frank MH, Waaga AM, Geehan C, Sayegh MH, Briscoe DM. Human • endothelial cells facilitate indirect allorecognition. Journal of the American • Society of Nephrology. 1999;10:A3540. • Frank MH, Denton MD, Khoury SJ, Briscoe DM, Sayegh MH. Modulators of • P-glycoproteinmediated transmembrane transport inhibit T-cell proliferation • in vitro. Transplantation. 1999;67 (S63):A225. • Frank MH, Denton MD, Alexander SI, Khoury SJ, Sayegh MH, Briscoe DM. • P-glycoprotein blockade inhibits alloimmune T cell activation in vitro. XVIII • International Congress of the Transplantation Society, Rome, Italy, 2000. • 2000:p161: Abstract POO26W. • Frank MH, Chitnis T, Abdallah KA, Sayegh MH, Khoury SJ. Tamoxifen inhibits • disease expression in murine experimental autoimmune encephalomyelitis. • Neurology. 2000;54(7 Suppl 3):A61. • Frank MH, Sayegh MH, Briscoe DM. P-glycoprotein function in human • alloimmune interactions. Pediatric Transplantation. 2000;4 (Supplement • No. 2):108: Abstract 0178. • Frank MH, Sayegh MH, Briscoe DM. P-glycoprotein function in alloimmune • lymphocyte/endothelial cell interactions. Journal of the American Society • of Nephrology. 2000;11:661A: A3485. • Frank MH, Sayegh MH, Briscoe DM. P-glycoprotein function in human • alloimmune interactions. Transplantation. 2000;69(8):A78. • Frank MH, Sayegh MH, Briscoe DM. P-glycoprotein blockade inhibits • alloimmune T cell responses via both CD4+ T cell- and CD14+ • APC-dependent activation pathways. American Journal of Transplantation. • 2001;1(Supplement 1):267: Abstract# 527. • Pendse S, Sayegh, MH, Frank MH. A critical role for P-glycoprotein in early • cytokine-dependent dendritic cell maturation. American Journal of • Transplantation 2002. 2002;2(Supplement 3):265: Abstract# 504. • Pendse S, Sayegh, MH, Frank MH. MDR1 P-glycoprotein blockade inhibits early • cytokinedependent dendritic cell differentiation. Journal of the American • Society of Nephrology. 2002;13:53A. • Izawa A, Frank NY, Pendse S, Sayegh MH, Frank MH. P-glycoprotein blockade • prolongs murine cardiac allograft survival. Circulation. 2003;108(17):IV-331 • Abstract 1554. • Frank NY, Pendse S, Lapchak PH, Doeing C, Sayegh MH, Frank MH. Regulation • of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding • cassette transporter. American Journal of Human Genetics. 2003;73 • (5 Supplement):327 Abstract 921. • Izawa A, Pendse S, Sayegh MH, Frank MH. MDR1 Specific pharmacologic • P-glycoprotein blockade prolongs murine cardiac allograft survival. American • Journal of Transplantation. 2003;3(Supplement 5):447: Abstract# 1153. • Pendse S, Behjati S, Sayegh MH, Frank MH. MDR1 P-glycoprotein is a dendritic • cell/macrophage differentiation switch in antigen presenting cell maturation. • American Journal of Transplantation. 2003;3(Supplement 5):340: • Abstract# 732. • Frank N, Frank MH, Gussoni E. ABCB5 P-glycoprotein is a molecular marker of • the Hoechst 33342 side population phenotype among human fetal skeletal • muscle cells. The FASEB Journal. 2004;18(4):A183: Abstract 144.9. • Margaryan A, Pütz P, Sayegh MH, Frank MH. Skin-derived ABCB5+ • progenitors can be induced to generate insulin-secreting cells in vitro. • The Cell Transplant Society 7th International Congress, Boston, USA, • November 17-20, 2004. 2004;18:Abstract 124. • Margaryan A, Sayegh MH, Frank MH. In vitro generation of insulin-secreting • cells from adult skin-derived ABCB5+ progenitors. Journal of the American • Society of Nephrology. 2004;15:647A. • Izawa A, Frank NY, Pendse SS, Margaryan A, Sho M, Sayegh MH, Frank MH. • In vivo regulation of Th1 responses and murine cardiac allograft rejection by • multidrug resistance Pglycoprotein. American Journal of Transplantation. • 2004;4(Supplement 8):412: Abstract# 931. • Frank NY, Margaryan A, Huang Y, Waaga-Gasser AM, Gasser M, Sayegh MH, • Sadee W, Frank MH. ABCB5-mediated doxorubicin transport and • chemoresistance in human malignant melanoma. Proceedings of the American • Association for Cancer Research. 2005;46:554 Abstract #2362. • Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, • Sayegh MH, Sadee W, Frank MH. ABCB5-mediated chemoresistance in human • malignant melanoma. 13th SPORE Investigators' Workshop,Washington, DC, • July 9-12, 2005. 2005:150 Abstract #149. • Rigol N, Frank NY, Margaryan A, Schatton T, Frank MH. Differential expression • of ABCB5 multidrug resistance P-glycoprotein in human breast cancer cell • lines. Proceedings of the Department of Defense Breast Cancer Research • Program Meeting (Era of Hope), June 8-11, 2005, Philadelphia, PA. 2005:467 • Abstract P66-7. • Schatton T, Yamaura K, Kupper TS, Sayegh MH, Murphy GF, Frank MH. • ABCB5: A Novel Molecular Marker For Melanoma Stem Cells? The Tony • & Shelly Malkin Stem Cell Symposium, Harvard Stem Cell Institute, • Boston, MA. 2005. • Schatton T, Murphy GF, Frank NY, Yamaura K, Zhan Q, Rigol N, Margaryan A, • Jordan S, Duncan LM, Kupper TS, Sayegh MH, Frank MH. The chemoresistance • mediator ABCB5 identifies melanoma stem cells. National Cancer Institute • 14th SPORE Investigators' Workshop. 2006:Abstract 150, p. 92. • Schatten S, Yang J, Chandraker A, Sayegh MH, Frank MH. In vivo • immunomodulatory function of ABCB5+ dermal mesenchymal stem cells. • American Journal of Transplantation. 2006;Supplement(World Transplant • Congress):Abstract 351: pp. 185-186.